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It is due to this fact affordable to assess response to treatment after a interval of about 6-eight weeks, and continue therapy if the drug has had a optimistic effect. In any other case, different strategies (equivalent to growing treatment strength, switching remedies, or including on remedies) must be tried. Switching to another topical drug that causes much less irritation (for example a topical antibiotic or azelaic acid). If there has been no enchancment, proceed treatment for as much as 3 months before assessing the effectiveness of remedy.

Oral isotretinoin acts on the four components concerned within the pathogenesis of acne. It's used for essentially the most severe circumstances of pimples, or in cases where different therapies cause continued relapse or can not prevent scarring. Girls taking oral isotretinoin cannot be pregnant on the time of initiating therapy, and can't grow to be pregnant during treatment or one month after stopping remedy, resulting from birth defects caused by the drug. A strict contraception regimen should be followed.

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